Atypical coverage, gram coverage and some gram -, QT prolongation esp erythro and clarithro, alternative for PCN allergy, hepatically cleared, Azithromycin renally dosed when CrCl 10 ml/min
Cover gram negative bugs, concentration dependent killing, post antibiotic effect, nephrotoxic, ototoxic, neurotoxic, pregnancy category D, dose on IBW or Adjusted BW, renally dosed
Inhibits bacterial protein synthesis by binding to 30S ribosomal subunit